Dominant-Negative Mutants as Antiviral Agents: Simultaneous Infection with the Cold-Adapted Live-Virus Vaccine for Influenza A Protects Ferrets from Disease Produced by Wild-Type Influenza A
Identifieur interne : 002029 ( Main/Exploration ); précédent : 002028; suivant : 002030Dominant-Negative Mutants as Antiviral Agents: Simultaneous Infection with the Cold-Adapted Live-Virus Vaccine for Influenza A Protects Ferrets from Disease Produced by Wild-Type Influenza A
Auteurs : Patricia Whitaker-Dowling [États-Unis] ; Hunein F. Maassab [États-Unis] ; Julius S. Youngner [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1991.
Abstract
The attenuated cold-adapted strain of influenza A virus that is a candidate live-virus vaccine suppressed clinical disease in ferrets when given simultaneously with a virulent epidemic strain of influenza A virus. The cold-adapted virus effectively prevented disease, even when the epidemic strain was of a different subtype than the attenuated virus. In this case, ferrets given a mixed inoculum produced antibody to both subtypes in the absence of clinical disease, indicating that both viruses are replicating in the respiratory tract. These findings suggest the possibility of the development of a novel class of antivirals for influenza, namely a live virus that is a dominant negative attenuated mutant that interferes with the replication of epidemic strains of virus.
Url:
DOI: 10.1093/infdis/164.6.1200
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000F90
- to stream Istex, to step Curation: 000F90
- to stream Istex, to step Checkpoint: 000D71
- to stream Main, to step Merge: 002128
- to stream Main, to step Curation: 002029
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Dominant-Negative Mutants as Antiviral Agents: Simultaneous Infection with the Cold-Adapted Live-Virus Vaccine for Influenza A Protects Ferrets from Disease Produced by Wild-Type Influenza A</title><author><name sortKey="Whitaker Dowling, Patricia" sort="Whitaker Dowling, Patricia" uniqKey="Whitaker Dowling P" first="Patricia" last="Whitaker-Dowling">Patricia Whitaker-Dowling</name></author><author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name></author><author><name sortKey="Youngner, Julius S" sort="Youngner, Julius S" uniqKey="Youngner J" first="Julius S." last="Youngner">Julius S. Youngner</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:741458032C280FAA5C1DEB5446C929BB0EAF1CB2</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1093/infdis/164.6.1200</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-9FM3BBLD-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000F90</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F90</idno><idno type="wicri:Area/Istex/Curation">000F90</idno><idno type="wicri:Area/Istex/Checkpoint">000D71</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D71</idno><idno type="wicri:doubleKey">0022-1899:1991:Whitaker Dowling P:dominant:negative:mutants</idno><idno type="wicri:Area/Main/Merge">002128</idno><idno type="wicri:Area/Main/Curation">002029</idno><idno type="wicri:Area/Main/Exploration">002029</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dominant-Negative Mutants as Antiviral Agents: Simultaneous Infection with the Cold-Adapted Live-Virus Vaccine for Influenza A Protects Ferrets from Disease Produced by Wild-Type Influenza A</title><author><name sortKey="Whitaker Dowling, Patricia" sort="Whitaker Dowling, Patricia" uniqKey="Whitaker Dowling P" first="Patricia" last="Whitaker-Dowling">Patricia Whitaker-Dowling</name><affiliation wicri:level="4"><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><affiliation wicri:level="4"><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Youngner, Julius S" sort="Youngner, Julius S" uniqKey="Youngner J" first="Julius S." last="Youngner">Julius S. Youngner</name><affiliation wicri:level="4"><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1991-12">1991</date><biblScope unit="vol">164</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1200">1200</biblScope><biblScope unit="page" to="1202">1202</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The attenuated cold-adapted strain of influenza A virus that is a candidate live-virus vaccine suppressed clinical disease in ferrets when given simultaneously with a virulent epidemic strain of influenza A virus. The cold-adapted virus effectively prevented disease, even when the epidemic strain was of a different subtype than the attenuated virus. In this case, ferrets given a mixed inoculum produced antibody to both subtypes in the absence of clinical disease, indicating that both viruses are replicating in the respiratory tract. These findings suggest the possibility of the development of a novel class of antivirals for influenza, namely a live virus that is a dominant negative attenuated mutant that interferes with the replication of epidemic strains of virus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Whitaker Dowling, Patricia" sort="Whitaker Dowling, Patricia" uniqKey="Whitaker Dowling P" first="Patricia" last="Whitaker-Dowling">Patricia Whitaker-Dowling</name></region><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name><name sortKey="Youngner, Julius S" sort="Youngner, Julius S" uniqKey="Youngner J" first="Julius S." last="Youngner">Julius S. Youngner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002029 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002029 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:741458032C280FAA5C1DEB5446C929BB0EAF1CB2
|texte= Dominant-Negative Mutants as Antiviral Agents: Simultaneous Infection with the Cold-Adapted Live-Virus Vaccine for Influenza A Protects Ferrets from Disease Produced by Wild-Type Influenza A
}}
| This area was generated with Dilib version V0.6.33. |  |